The Impact of High Grade Glioma Extent of Resection on the Early Post-Operative Period
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- Category: Vol. 93, March 2025
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The Impact of High Grade Glioma Extent of Resection on the Early Post-Operative Period, MAHMOUD A. GOMAA, HESHAM A. ELSHITANY, MOHAMED S. YASSIN and AMR FATHIGOMAA
Abstract
Background: Microsurgical resection of high grade glio-mas is considered the cornerstone management for most pa-tients. However, the evidence available in the scientific litera-ture on the effectiveness of the excision extent is scarce. A rule of thumb in neurosurgical oncology is that radical tumor re-section improves survival. This rule, however, must be applied with caution as functional loss after resection is not uncommon. We conducted this study to investigate the impact excision ex-tent of high-grade Glioma on the early post-operative clinical outcome of the patients. Extent of resection will be judged by postoperative MRI brain with gadolinium enhancement within 48 hours of surgery.
Aim of Study: To evaluate the impact of extent of resection of high-grade Gliomas on the early post-operative clinical out-come of the patients. Extent of resection will be judged by post operative MRI brain with contrast within 48 hours of surgery.
Patients and Methods: This study was conducted on 25 patients with high-grade gliomas. This is a prospective study that had been held at the Neurosurgery Department at Fayoum University Hospital & Cairo University Hospital between Feb-ruary 2021 and November 2021. All patients with supra-tento-rial cortical and subcortical high-grade gliomas were included in our study.
Results: The association between residual percentage and the ICU length of stay was studied using Spearman’s correla-tion which showed a strong positive correlation between them, correlation coefficient = 0.85 and p-value <0.001. A higher percentage of the residual is associated with Longer ICU ad-mission. There was a statistically significant difference between those who improved and those who did not. Patients who stayed the same with no improvement had a larger percentage of re-sidual.
Conclusion: We proved that in this study the impact of a higher degree of resection was related to improving better outcome in symptoms immediately postoperative with a lower incidence of complications and fewer ICU days and decreasing the need for massive dehydration measures.