Descriptive Analysis of a Comparison between Lung Ultrasound and HRCT in Patients of Connective Tissue Disease Associated Interstitial Lung Disease
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- Category: Vol. 93, March 2025
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Descriptive Analysis of a Comparison between Lung Ultrasound and HRCT in Patients of Connective Tissue Disease Associated Interstitial Lung Disease, DINA A. ELSAYED, SABAH A. MOHAMED, AHMED ABDEL MOHSEN M. ABDULLAH and TAKEYA A. TAYMOUR
Abstract
Background: In order to determine the diagnostic perfor mance of lung ultrasound in comparison with HRCT, thirty five patients with known history of positive features of interstitial lung diseases related to connective tissue diseases were recruit ed in a prospective study. The patients’ ages ranged from 18 to 74 years with a mean age of 43.3 years. They were evaluated by LUS and standard high resolution CT chest study (HRCT). Aim of Study: This study was to investigate the diagnos tic accuracy of the LUS in the evaluation of interstitial lung disease changes due to systemic connective tissue disease in comparison to HRCT. Subjects and Methods: In the duration from August 2022 to January 2023, 35 patients with known history of connective tissue diseases and showing positive diagnostic features of in terstitial lung diseases participated in this prospective study. All patients had thoracic ultrasound followed by high resolution CT chest examination following taking their consents. After wards, final cases interpretation and data collection were done. Results: Following comparison and correlation with HRCT, LUS had sensitivity of 94.3%, specificity of 0% (as there were no negative results), PPV of 94.3% with an overall accuracy of 94.3% for the diagnosis of ILDs. There was a significant posi tive correlation between the frequency of abnormalities detect ed by HRCT and LUS. Conclusions: LUS is a low-cost, non-invasive, radia tion-free and portable tool that can be rapidly performed. How ever, it only assesses 70% of the lung surface, and only chang es close to the pleural surface can be seen as well as it lacks specificity to ILD. In addition, LUS cannot identify the central or peri-hilar regions when compared to HRCT, so it could rep resent a complementary screening, evaluating and follow-up approach of CTD-ILD.