Magnetic Resonance Spectroscopic Grading of Intracranial Gliomas: Diagnostic Reliability at Different Echo Times
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- Category: Vol. 85, December 2017
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Magnetic Resonance Spectroscopic Grading of Intracranial Gliomas: Diagnostic Reliability at Different Echo Times, WESSAM A. EL-ZAYAT and MONA EL-KALIOUBIE
Abstract
Purpose: Our aim was to assess the role of proton magnetic resonance spectroscopy 1H MRS at different echo times (TE) in grading cerebral gliomas.
Patients and Methods: We retrospectively analyzed the spectra of 48 patients with untreated gliomas, classified as high and low grade on histopathological basis. We calculated Cho/Cr, Cho/NAA, NAA/Cr and mI/Cr metabolite ratios, at short and intermediate TE. Metabolites ratios at different TE were compared using unpaired student t-test. Receiver Oper-ating Characteristic (ROC) curves assessed the predictive power of different TEs in glioma grading.
Results: Based on histopathology, we reported 28 (58.3%) low grade and 20 (41.7%) high grade gliomas. Short TE Cho/Cr, Cho/NAA metabolic ratios were significantly greater in high grade gliomas, while short TE mI/Cr metabolic ratio was significantly lower in high grade gliomas. At intermediate TE, the only metabolic ratio showing statistical significance was Cho/Cr. ROC curve analysis revealed better diagnostic accuracy for Cho/Cr at short TE than intermediate TE (91.7% versus 75%).
Conclusion: In conclusion, our results suggested that short TE 1H MRS provided a better diagnostic outcome than intermediate TE in the setting of grading cerebral gliomas.