Ferritin and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
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- Category: Vol. 77, March 2009
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Ferritin and Insulin Resistance in Patients with Type 2 Diabetes Mellitus,SOAD SULTAN, AMR AL-MELIGI, NAGWA ALTAWEEL and HALA ABD ELAZEM
Abstract
Diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbance of carbohydrate, fat and protein metabolism associated with relative or absolute deficiency of insulin secretion and/or insulin action. Ferritin is the major iron storage protein and plays a key role in iron metabolism. In general population, body iron stores are positively associated with the development of glucose intolerance, type 2 diabetes. The aim of the present study was to measure serum ferritin in patients with type 2 diabetes and to study the relationship between serum ferritin, fasting blood glucose, glycated hemo-globin, insulin level and insulin resistance in patients with type 2 diabetes mellitus. This study involved 40 female patients in child bearing period with type 2 diabetes mellitus selected from diabetes and endocrine clinic in Kasr El-Aini Hospital. Twenty healthy, age matched, females were taken as a control group. All subjects were subjected to: History taking, clinical examination and laboratory Investigation including fasting plasma glucose, glycated hemoglobin (HbA1c), fasting insulin and serum ferritin. We found that serum ferritin was signifi-cantly higher in patients with type 2 DM compared with the control group (p<0.001) and in patients with type 2 DM ferritin level was positively correlated with fasting blood glucose (p<0.001), glycated hemoglobin (p<0.001), fasting insulin level (p<0.05) and insulin resistance (p<0.001).