YKL-40 as a New Biomarker in Asthmatic Children and Asthmatic Exacerbation. Its Role and Correlations with Eosinophil's Percentage and Serum IgE Level,
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- Category: Vol. 89, September 2021
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YKL-40 as a New Biomarker in Asthmatic Children and Asthmatic Exacerbation. Its Role and Correlations with Eosinophil's Percentage and Serum IgE Level, MAHMOUD M. ZAHRAN, EHAB IBRAHIM I. SOROUR and HESHAM S.M. ELBAZ
Abstract
Background: YKL-40 is a member of the mammalian chitinase like protein class of 40 Kda (kilo Dalton) heparin binding glycoprotein. Its name is derived from the protein's molecular weight and three N-terminus amino acids (tyrosine [y], lysine [k] and leucine [l]). YKL-40 is secreted by various cell-types including macrophages, chondrocytes, and some types of cancer cells. The exact physiological role of YKL-40 is not known, but it has been implicated in cell development, inflammatory disease such as asthmaand cancer progression. Aim of Study: This study was to investigate whether serum YKL-40 were increased in Asthmatic children and identify its correlation with acute exacerbation, total IgE, blood Eosinophil percentage (EO%) and Pulmonary Function (PF). We measured serum YKL-40 levels, EO%, and serum IgE in 30 children with Asthma as well as in 20 apparently healthy controls from the communities surrounding AL-Salama Hospital, EL-Khobar district, Saudi Arabia. Pulmonary Func-tion (PF) of Asthmaticpatients was also measured. Patients and Methods: Our data showed that the serum YKL-40 was significantly elevated in patients with Asthma (77.66ng/mL) compared with control (55.16ng/mL) (p=0.001) and when Asthma patients were stratified, serumYKL-40 levels in exacerbation group were significantly higher (83.72ng/ mL) than those in stable Asthmatic group (77.66ng/mL) (p=0.043). Results: In addition, serum YKL-40 was correlated posi-tively with the level of IgE (with r=0.298 and p=0.018) and EO% (with r=0.272 and p=0.032) but negatively correlated to pulmonary functions as Forced Expiratory Volumein 1st second (FEV1) (with r=–0.044 and p=0.0001). Thus, we conclude that YKL-40 is found significantly high in the serum of asthmatic childrenand its level correlates with exacerbation attacks, indicating that high levels of serum YKL-40 may be biological characteristic of the asthma exac-erbation. Conclusion: In our study, we conclude that serum YKL-40 level are increased in asthmatic children patients and its level correlates with exacerbation attacks indicating that YKL-40 may be either a cause or a new biomarker for asthma and its disease severity.