Kidney Injury Molecule-1, Sensitivty and Specificity for Diagnosis of Acute Kidney Injury in Pediatric Cardiac Population, SARA A. KASEM, AZZA M. EZZAT, WAFAA M. EL-SADEK, AHMED M. EL-HADDAD, AHMED LOTFY, AMIRA M. EL-KHATTEB and OLFAT G. SHAKER
Abstract
Background: A uniform and precise operational definition of acute kidney injury formerly Acute Renal Failure (ARF) has remained somewhat elusive. All definitions till now are based on serum creatinine that lacks the ability to early identify AKI. Some new markers such as Kidney Injury Molecule-1 (KIM-1) were introduced recently to predict AKI. We try to validate this biomarker in pediatric patients undergoing cardiopulmonary bypass.
Methods: 72 pediatric patients with acyanotic congenital heart disease for total correction were included. Serum crea-tinine was measured after 24 hours postoperatively in the ICU to diagnose AKI. Two urine samples were taken, one preop-eratively (baseline) and the other after 24 hours of the operation for quantitation of KIM-1.
Results: Sensitivity and specificity of KIM-1 in AKI in pediatric cardiac patients was done using AUROC curve which was 0.567 with sensitivity of 51.72 and specificity of 72.9. The cut of value was >421.6pg/ml (95% confidence interval (0.444-0.683).
Conclusion: KIM-1 as a early biomarker of AKI in pedi-atric cardiac population has weak sensitivity and specificity.