Possible Effect of Carbamazepine A Sodium Channel Blocker on Urinary Bladder Dysfunction in Type-1 Diabetic Patients,
/ 0
- Details
- Category: Vol. 84, March 2016
- Hits: 651
Possible Effect of Carbamazepine A Sodium Channel Blocker on Urinary Bladder Dysfunction in Type-1 Diabetic Patients, MAGDA ZAKI, HISHAM ATTIA, HESHAM M. MAHMOUD, HOSNI KHAIRI and AMR MAHER
Abstract
Background: Diabetic cystopathy is a complication of diabetes mellitus; it usually develops in diabetic patients with long-standing and poorly controlled disease. It has been found that the urothelium epithelial sodium channels enhance release of excitatory agents on afferent neurons upon bladder stretch.
Objective: In the present study the therapeutic effect of Carbamazepine in the management of Overactive Bladder (OAB) in diabetic patients.
Material and Methods: Fifty males and females patients with type-1 diabetes mellitus and OAB randomly assigned in the present study to use Placebo 5mg/12hrs for one month, Tolterodine 2mg/12hrs for one month or Carbamazepine 100mg/12hrs for one month.
Results: Tolterodine treatment significantly decreased voiding diary parameters (urgency/day, urgency incontinence/ week, frequency of micturition/day and nocturia episodes/day) and cystometric estimated bladder capacities (first desire capacity and maximum bladder capacity) compared to placebo group, while Carbamazepine treatment showed insignificant decrease in most of voiding diary parameters and an insignif-icant increase in bladder capacities compared to that of placebo group. However, Carbamazepine significantly reduced urgency compared to placebo group.
Conclusion: A part from reducing the urgency of mictu-rition compared to placebo group, the present study didn't show a significant role for carbamazepine in improving the voiding diary parameters and all bladder capacities. A further clinical study with higher doses of Carbamazepine as well as bigger sample size are required.