Effects on the Maternal Nausea and Vomiting after Giving Prophylactic Ephedrine Versus Phenylephrine for Prevention of Hypotension in Severe Pre-Eclamptic Parturients Uundergoing Cesarean Section Under Spinal Anesthesia,
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Effects on the Maternal Nausea and Vomiting after Giving Prophylactic Ephedrine Versus Phenylephrine for Prevention of Hypotension in Severe Pre-Eclamptic Parturients Uundergoing Cesarean Section Under Spinal Anesthesia, MOHAMED Y. MOHAMED, JEHAN H. IBRAHIM and TAMER F. SAFAN
Abstract
Objective: Is to compare the incidence of of nausea and vomiting after giving phenylephrine and ephedrine for the prevention of spinal anesthesia induced hypotension in severe preeclamptic patients undergoing cesarean delivery.
Methods: 60 severely pre-eclamptic patients randomly allocated into 2 equal groups (30 patients each) using computer generated numbers and concealed using sequentially numbered, sealed opaque envelope technique.
Group E (ephedrine): Patients received bolus of 10 mil-ligram of ephedrine i.v immediately after the subarachnoid block.
Group P (phenylephrine): Patients received bolus of 100 microgram of phenylephrine i.v immediately after the sub-arachnoid block.
Nausea and vomiting were observed, recorded preopera-tive, intraoperative and postoperative. They were treated by atropine if occurred intraoperative or ondansetron if occurred postoperative.
Results: Intraoperatively, in ephedrine group, four patients suffered from nausea and one patient suffered from vomiting and they were treated by 0.5mg atropine. While in phenyle-phrine group, no patients suffered from nausea or vomiting.
Conclusion: Ephedrine administration is associated with higher incidence of nausea and vomiting in the mother.