Association of Pro-Inflammatory Leptin with Metabolic Syndrome in Obese Egyptian Women
/ 0
- Details
- Category: Vol. 84, March 2016
- Hits: 706
Association of Pro-Inflammatory Leptin with Metabolic Syndrome in Obese Egyptian Women, SALWA M. EL SHEBINI, MONA A. MOHAMED, HESHAM MOTTAWIE, SALWA S. SOLIMAN and HEND A. ESSA
Abstract
Background: Obesity and its complications including metabolic syndrome (MetS) have been increased recently especially visceral obesity. Leptin has a role in pathogenesis of obesity.
Aim of the Study: The objective of this study was to evaluate the relationship between Leptin, and metabolic syndrome in obese women.
Method: This study was carried out on sixty three women shared as volunteers with mean age 44.7, and mean body mass index (BMI) 24.86 for control and 46.73 for obese. Clinical examination and blood pressure were performed for each patient. Anthropometric measurements for Weight, Height, Body mass index (BMI), Mid Waist Circumference (MWC), hip circumference (HC), waist/hip Ratio (WHR), % of body fat (%BF), basal metabolic rate (BMR) were reported. Fasting blood samples were taken to measure the biochemical indica-tors: Fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG) and high density lipoprotein- cholesterol (HDL-C), Low density lipoprotein -cholesterol (LDL-C) very low density lipoprotein-cholesterol (VLDL-C) and TC/HDL ratio was calculated. Serum levels of Leptin and Insulin hormone were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated.
Results: Forty three were women were diagnosed as metabolic syndrome (MetS) patients according to The National Cholesterol Education Program: Adult treatment Panel III. MetS obese group showed a significant difference in Weight, BMI, MWC, HC, and WHR, % BF, BMR and Systolic Blood Pressure compared to control. Fasting Blood Glucose, TG, TG, LDL-C, VLDL-C, and TC/HDL-C ratio were significantly higher in MetS obese women with significant reduction in HDL- compared to control group. Leptin and HOMA-IR were significantly higher in obese than control women. Moreover this study demonstrated a significant positive correlation between leptin and BMI, WHR and insulin in MetS obese group.
Conclusion: The data of this study found a change in the anthropometric, measurements especially visceral obesity and the serum lipid profile was concomitant with hormonal change in the leptin level in MetS obese women. Indeed leptin was associated with obesity, indicating a high risk for obese persons to develop hypertension, type 2 diabetes mellitus, and cardio-vascular disease.