Differential Diagnosis of ACS by Copeptin in Emergency Department,
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- Category: Vol. 84, June 2016
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Differential Diagnosis of ACS by Copeptin in Emergency Department, HOSSAM A. SHAHIN, SABAH F. EL-ABD, EMAD F. ABD EL-MAKSOUD and WAEL S. ABD EL-MAGEED
Abstract
Background: ACS patients presented to ED require rapid differential diagnosis. Although troponin is the gold marker for ACS, there is still cases that can't be diagnosed in the early stages.
Aim of Work: The aim of this study was to investigate copeptin levels in ACS patients and compare them for a cut off level for each ACS case. Also, to compare copeptin to cTnI, CRP to differentiate between ACS type on admission.
Subjects and Methods: Sixty two consecutive patients with ACS presenting to the Emergency Department of the National Heart Institute, Giza (Egypt) between March and June 2014, were recruited for the study, grouped into two groups according to the final diagnosis as AMI (including thirty two patients) and UA (including thirty patients) groups. Their cardiac markers and copeptin levels were assayed and compared to a control healthy group on admission and after 6 hours.
Results: Results revealed significant difference between cardiac levels on admission compared to that obtained after six hours. Only copeptin levels were diagnosing on admission (higher with clear cut off levels) compared to that of six hours (decreased and get non significant differences).
Conclusion: Early measurement of the combination of troponin I and copeptin may revolutionize the diagnostic accuracy and therapeutic decision-making in patients with symptoms suggestive of ACS, differentiate between UA or AMI patients on admission.