Relation of Immunoglobulin A Isotype of Anti-ß2 Glycoprotein I to Clinical and Laboratory Features of Antiphospholipid Syndrome and Systemic Lupus Erythematosus
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- Category: Vol. 82, December 2014
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Relation of Immunoglobulin A Isotype of Anti-ß2 Glycoprotein I to Clinical and Laboratory Features of Antiphospholipid Syndrome and Systemic Lupus Erythematosus, AZZA H. ELAWAR,TAMER M.A. GHEITA, DOAA H. SAYED, MAGDA I.M. AYOUB and ASMAA M. ABD-ALAAL
Abstract
Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to components of the cell nucleus. Antiphos-pholipid syndrome (APS) is the most common type of acquired thrombophilias. The diagnosis of APS should be made on the presence of the characteristic clinical manifestations of throm-bosis/pregnancy morbidity and the presence persistently positive antiphospholipid antibodies [aPL] (anticardiolipin [aCL] IgM/IgG or anti-ß2 glycoprotein I [anti-ß2GPI] IgM/IgG), lupus anticoagulant [LA] or both.
Aim of the Work: Clarifying the significance of anti-ß2GPI of IgA isotype among Egyptian lupus patients with and without APS regarding clinical and laboratory features of both diseases.
Patients and Methods: The study included 54 SLE patients. Twenty seven (50%) of those patients had no APS while the other half had secondary APS. Patients with other known causes of thrombophilia were excluded. Twenty seven appar-ently normal age and sex-matched Egyptian control persons were included. Patients were subjected to clinical assessment and routine laboratory tests. Both patients and controls were evaluated for the presence of lupus anticoagulant, anti-ß2GPI of IgM, IgG and IgA isotype as well as aCL of IgM, IgG and IgA isotypes.
Results: Dural sinus thrombosis and autoimmune throm-bocytopenia were significantly more common in patients with positive anti -ß2GPI IgA (p-value: 0.025 and 0.03 respectively).
Conclusion: Anti -ß2GPI of IgA isotype seems to contribute to the pathogenesis of thrombotic and non thrombotic mani-festations of SLE and APS i.e. dural sinus thrombosis and autoimmune thrombocytopenia.