Case Report: G-CSF Induced Posterior Reversible Leukoencephalopathy Syndrome and SLE Flare Up
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- Category: Vol. 81, September 2013
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Case Report: G-CSF Induced Posterior Reversible Leukoencephalopathy Syndrome and SLE Flare Up, SAIF A. ALQAHTANI, ABDULLAH I. AEDH, MOHAMMED A. ALHAMADI and HYDER A. OMAR
Abstract
Background: Granulocyte-colony stimulating factor (G-CSF) is a glycoprotein which stimulates the survival, prolif-eration, differentiation and function of neutrophil, granulocyte progenitor cells and mature neutrophils. G-CSFs have been used to improve granulocyte count in neutropenic patients, reduce the incidence and duration of neutropenia in SLE patient. In general, side-effects are mild to moderate and life threatening side-effects like severe SLE flare up and posterior reversible leukoencephalopathy syndrome are very rare.
Case Report: We report a case of SLE patient who devel-oped severe systemic lupus erythematosus (SLE) flare up and posterior reversible leukoencephalopathy syndrome (PRES) secondary to G-CSF. This case emphasizes the diagnostic and therapeutic challenges in the management of SLE.